Literature Review: Correlation Between Obesity, Testosterone Replacement Therapy, and Brain Health

Close-up photo of an overweight man holding a bowl of food

Introduction The interplay between obesity, testosterone replacement therapy (TRT), and brain health has garnered significant attention in recent years. Obesity and hypogonadism (low testosterone), both of which are common in older men, are associated with cognitive decline. This review aims to synthesize current research findings on how TRT, when combined with lifestyle interventions, affects cognitive […]

Literature Review: Does Testosterone Replacement Therapy Cause Mood Swings?

Angry man yelling and pounding his fist on a table.

Testosterone replacement therapy (TRT) is primarily used to address symptoms of testosterone deficiency, such as fatigue, decreased libido, erectile dysfunction, and depressed mood. This is done by increasing serum testosterone levels to a physiological range (1). The impact of TRT on mood has been extensively studied, with mixed results regarding its potential to cause mood swings. […]

Literature Review: Does Testosterone Replacement Therapy Cause Prostate Cancer?

Scrabble tiles spelling prostate cancer

Introduction Testosterone replacement therapy (TRT) has been a subject of significant debate, particularly concerning its safety in regards to prostate cancer. Historically, TRT was believed to cause prostate cancer and that increased testosterone levels could stimulate prostate cancer growth. However, recent studies have begun to challenge this notion, suggesting that TRT may not pose a […]